Title: the Sex-limited Effects of Mutations in the Egfr and Tgf-β Signaling Pathways on Shape and Size

نویسندگان

  • Nicholas D. Testa
  • Ian Dworkin
چکیده

1 sexual dimorphism and allometry in the Drosophila wing. Abstract: Much of the morphological diversity in nature−including among sexes within a species−is a 32 direct consequence of variation in size and shape. However, disentangling variation in sexual dimorphism 33 for both shape (SShD), size (SSD) and their relationship with one another remains complex. Understanding 34 how genetic variation influences both size and shape together, and how this in turn influences SSD and 35 SShD is challenging. In this study we utilize Drosophila wing size and shape as a model system to 36 investigate how mutations influence size and shape as modulated by sex. Previous work has demonstrated 37 that mutations in Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor-β (TGF-38 β) signaling components can influence both wing size and shape. In this study we re-analyze this data to 39 specifically address how they impact the relationship between size and shape in a sex-specific manner, in 40 turn altering the pattern of sexual dimorphism. While most mutations influence shape overall, only a subset 41 have a genotypic specific effect that influences SShD. Furthermore, while we observe sex-specific patterns 42 of allometric shape variation, the effects of most mutations on allometry tend to be small. We discuss this 43 within the context of using mutational analysis to understand sexual size and shape dimorphism. 44 45. CC-BY-NC 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not .

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تاریخ انتشار 2016